Symbol
Name
ID

Diaph1
diaphanous related formin 1
MGI:1194490

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Menorrhagia	Post-partum hemorrhage	Impaired platelet aggregation	Thrombocytopenia	Macrothrombocytopenia
Disease(s) Associated with DIAPH1
autosomal dominant nonsyndromic deafness 1

Mouse Phenotypes

abnormal leukocyte migration

decreased T cell proliferation

increased spleen weight

abnormal definitive hematopoiesis

extramedullary hematopoiesis

anemia

abnormal bone marrow cell morphology/development

increased bone marrow cell number

echinocytosis

increased neutrophil cell number

increased granulocyte number

decreased B-1 B cell number

abnormal CD4-positive, alpha-beta T cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

abnormal CD8-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased effector memory CD8-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta memory T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

increased single-positive T cell number

decreased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal spleen morphology

abnormal spleen germinal center morphology

absent spleen white pulp

decreased IgE level

Availability

Mouse Genotype

Diaph1^M1Btlr/Diaph1^M1Btlr

Diaph1^M2Btlr/Diaph1^M2Btlr

Diaph1^m3Btlr/Diaph1^m3Btlr

Diaph1^tm1.1Sna/Diaph1^tm1.1Sna

Diaph1^tm1Asal/Diaph1^tm1Asal

Diaph1^M1Btlr/Diaph1⁺

Diaph1^M2Btlr/Diaph1⁺

Diaph1^tm1Asal/Diaph1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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